[HTML][HTML] Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
[HTML][HTML] Ethnicity and clinical outcomes in COVID-19: a systematic review and meta-analysis
Background Patients from ethnic minority groups are disproportionately affected by
Coronavirus disease (COVID-19). We performed a systematic review and meta-analysis to …
Coronavirus disease (COVID-19). We performed a systematic review and meta-analysis to …
[HTML][HTML] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
L Bergamaschi, F Mescia, L Turner, AL Hanson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …
Markers of immune activation and inflammation in individuals with postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection
MJ Peluso, S Lu, AF Tang… - The Journal of …, 2021 - academic.oup.com
Background The biological processes associated with postacute sequelae of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. Methods …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. Methods …
Association of psychiatric disorders with mortality among patients with COVID-19
K Nemani, C Li, M Olfson, EM Blessing… - JAMA …, 2021 - jamanetwork.com
Importance To date, the association of psychiatric diagnoses with mortality in patients
infected with coronavirus disease 2019 (COVID-19) has not been evaluated. Objective To …
infected with coronavirus disease 2019 (COVID-19) has not been evaluated. Objective To …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
[HTML][HTML] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Abstract Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19
JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …
[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …
responses and COVID-19 disease severity. We completed a combined examination of all …
[HTML][HTML] Cytokine storm
DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …
immune-cell hyperactivation, has various causes and is characterized by constitutional …