Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
J Chalmers, H Abo-Leyah, H Loftus, M Spears… - …, 2021 - discovery.dundee.ac.uk
Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients
admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods …
admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods …
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
Emerging telemedicine tools for remote COVID-19 diagnosis, monitoring, and management
The management of the COVID-19 pandemic has relied on cautious contact tracing,
quarantine, and sterilization protocols while we await a vaccine to be made widely available …
quarantine, and sterilization protocols while we await a vaccine to be made widely available …
[PDF][PDF] Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
[HTML][HTML] Sex differences in immunity to viral infections
H Jacobsen, SL Klein - Frontiers in immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …
[PDF][PDF] COVID-19 and cancer: current challenges and perspectives
Patients with cancer have been disproportionately affected by the COVID-19 pandemic. This
effect has included the adverse outcomes in patients with cancer who develop COVID-19 …
effect has included the adverse outcomes in patients with cancer who develop COVID-19 …
Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity
Antiviral agents that complement vaccination are urgently needed to end the COVID-19
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells
A Rebendenne, AL Chaves Valadão, M Tauziet… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
F Karagiannis, K Peukert, L Surace, M Michla… - Nature, 2022 - nature.com
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
[HTML][HTML] Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline
JD Chalmers, ML Crichton… - European respiratory …, 2021 - Eur Respiratory Soc
Introduction Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …