Immunological imprinting of the antibody response in COVID-19 patients

T Aydillo, A Rombauts, D Stadlbauer, S Aslam… - Nature …, 2021 - nature.com
In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are
also susceptible to six other coronaviruses, for which consecutive exposures to antigenically …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Characterization and biomarker analyses of post-COVID-19 complications and neurological manifestations

B Sun, N Tang, MJ Peluso, NS Iyer, L Torres… - Cells, 2021 - mdpi.com
As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae
following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are …

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

G Jocher, V Grass, SK Tschirner, L Riepler… - EMBO …, 2022 - embopress.org
The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …

Association between tumor necrosis factor inhibitors and the risk of hospitalization or death among patients with immune-mediated inflammatory disease and COVID …

Z Izadi, EJ Brenner, SK Mahil, N Dand… - JAMA network …, 2021 - jamanetwork.com
Importance Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally
because of their ability to ameliorate shared immune pathways across immune-mediated …

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

J Declercq, KFA Van Damme, E De Leeuw… - The Lancet …, 2021 - thelancet.com
Summary Background Infections with SARS-CoV-2 continue to cause significant morbidity
and mortality. Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic …

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

RC Thompson, NW Simons, L Wilkins, E Cheng… - Nature Medicine, 2023 - nature.com
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

S Chakraborty, JC Gonzalez, BL Sievers… - Science Translational …, 2022 - science.org
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …