Combinatorial therapy in tumor microenvironment: where do we stand?
The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
Remodeling the epigenetic landscape of cancer—application potential of flavonoids in the prevention and treatment of cancer
W Jiang, T Xia, C Liu, J Li, W Zhang, C Sun - Frontiers in Oncology, 2021 - frontiersin.org
Epigenetics, including DNA methylation, histone modification, and noncoding RNA
regulation, are physiological regulatory changes that affect gene expression without …
regulation, are physiological regulatory changes that affect gene expression without …
Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate
Whole genome bisulphite sequencing (WGBS) permits the genome-wide study of single
molecule methylation patterns. One of the key goals of mammalian cell-type identity studies …
molecule methylation patterns. One of the key goals of mammalian cell-type identity studies …
Transgenerational DNA Methylation Changes in Daphnia magna Exposed to Chronic γ Irradiation
Our aim was to investigate epigenetic changes in Daphnia magna after a 25-day chronic
external γ irradiation (generation F0 exposed to 6.5 μGy· h–1 or 41.3 mGy· h–1) and their …
external γ irradiation (generation F0 exposed to 6.5 μGy· h–1 or 41.3 mGy· h–1) and their …
Potential role of DNA methylation as a driver of plastic responses to the environment across cells, organisms, and populations
There is great interest in exploring epigenetic modifications as drivers of adaptive
organismal responses to environmental change. Extending this hypothesis to populations …
organismal responses to environmental change. Extending this hypothesis to populations …
Insights into epigenome evolution from animal and plant methylomes
SV Yi - Genome biology and evolution, 2017 - academic.oup.com
Evolutionary studies of DNA methylation offer insights into the mechanisms governing the
variation of genomic DNA methylation across different species. Comparisons of gross levels …
variation of genomic DNA methylation across different species. Comparisons of gross levels …
Distinct epigenomic and transcriptomic modifications associated with Wolbachia-mediated asexuality
Wolbachia are maternally transmitted intracellular bacteria that induce a range of
pathogenic and fitness-altering effects on insect and nematode hosts. In parasitoid wasps of …
pathogenic and fitness-altering effects on insect and nematode hosts. In parasitoid wasps of …
Lineage and Parent-of-Origin Effects in DNA Methylation of Honey Bees (Apis mellifera) Revealed by Reciprocal Crosses and Whole-Genome Bisulfite Sequencing
X Wu, DA Galbraith, P Chatterjee… - Genome biology and …, 2020 - academic.oup.com
Parent-of-origin methylation arises when the methylation patterns of a particular allele are
dependent on the parent it was inherited from. Previous work in honey bees has shown …
dependent on the parent it was inherited from. Previous work in honey bees has shown …
A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing
J Liang, K Zhang, J Yang, X Li, Q Li… - Briefings in …, 2021 - academic.oup.com
Genetic and epigenetic contributions to various diseases and biological processes have
been well-recognized. However, simultaneous identification of single-nucleotide variants …
been well-recognized. However, simultaneous identification of single-nucleotide variants …
epialleleR: an R/Bioconductor package for sensitive allele-specific methylation analysis in NGS data
Low-level mosaic epimutations within the BRCA1 gene promoter occur in 5–8% of healthy
individuals and are associated with a significantly elevated risk of breast and ovarian …
individuals and are associated with a significantly elevated risk of breast and ovarian …