Mitral valve prolapse (MVP) is a commonly occurring heart condition defined by
enlargement and superior displacement of the mitral valve leaflet (s) during systole …

Traditional definitions of Ebstein's anomaly (EA) and left ventricular noncompaction (LVNC),
two rare congenital heart defects (CHDs), confine disease to either the right or left heart …

High-throughput DNA sequencing studies increasingly associate DNA variants with
congenital heart disease (CHD). However, functional modeling is a crucial prerequisite for …

The well-orchestrated turnover of proteins in cross-striated muscles is one of the
fundamental processes required for muscle cell function and survival. Dysfunction of the …

Patients with two congenital heart diseases (CHDs), Ebstein's anomaly (EA) and left
ventricular noncompaction (LVNC), suffer higher morbidity than either CHD alone. The …

Cardiac apoptosis has been identified as one of the main precipitating factors of heart failure
(HF) throughout the whole course of progressive disease. Limited to the lack of diagnostic …

Left ventricular non-compaction is a complex cardiomyopathy and the third largest childhood
cardiomyopathy, for which limited knowledge is available. Both pathogenesis and prognosis …

Only few copy number variants at chromosome 19p13. 11 have been reported, thus
associated clinical information is scarce. Proximal to these copy number losses, we now …

Ebstein anomaly and tricuspid valve dysplasia are the two most common malformations
affecting the tricuspid valve. Both lesions have a broad range of clinical presentations due to …

Congenital heart defects (CHDs) are cardiogenic malformations present at or before birth
and account for a high burden of neonatal morbidity and mortality. While traditional …