Proteomics is the field of study that includes the analysis of proteins, from either a basic
science prospective or a clinical one. Proteins can be investigated for their abundance …

Mass spectrometry has been widely used to analyze biological samples and has evolved
into an indispensable tool for proteomics research. Our desire to understand the proteome …

Proteomics is the large-scale study of the structure and function of proteins in complex
biological sample. Such an approach has the potential value to understand the complex …

A comparative study on the three quantitative methods frequently used in proteomics, 2D
DIGE (difference gel electrophoresis), cICAT (cleavable isotope-coded affinity tags) and …

The absolute need to improve the separating power of liquid chromatography, especially for
multi-constituent biological samples, is becoming increasingly evident. In response, over the …

Biotechnology increasingly delivers highly promising protein-based biopharmaceutical
candidates to the drug development funnel. For successful biopharmaceutical drug …

Integral membrane proteins (IMPs) lie at the critical junctions between intracellular
compartments and cells and their environment. As such, IMPs are in a unique position to …

Global bottom-up mass spectrometry (MS)-based proteomics is widely used for protein
identification and quantification to achieve a comprehensive understanding of the …

Hydrophilic interaction chromatography (HILIC) is becoming increasingly popular for
separation of polar samples on polar columns in aqueous‐organic mobile phases rich in …

Shotgun proteomics dominates the field of proteomics. The foundations of the strategy
consist of multiple rounds of peptide separation where chromatography provides the …