GSDMD in regulated cell death: A novel therapeutic target for sepsis

X Ma, Y Lin, L Zhang, S Miao, H Zhang, H Li… - International …, 2024 - Elsevier
Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an abnormal host
response to infection. Regulated cell death is essential for maintaining tissue homeostasis …

Cinnamaldehyde Downregulation of Sept9 Inhibits Glioma Progression through Suppressing Hif‐1α via the Pi3k/Akt Signaling Pathway

Z Wang, C Wang, J Fu, R Liu, X Zhou - Disease Markers, 2022 - Wiley Online Library
Purpose. Cinnamaldehyde (CA) is the main ingredient in cinnamon, and it has been proven
to have an inhibitory effect on many different tumor types. However, it lacks effect on glioma …

Identification and validation of autophagy‐related genes in exogenous sepsis‐induced acute respiratory distress syndrome

Y Xie, W Hu, X Chen, P Ren, C Ye… - Immunity …, 2022 - Wiley Online Library
Objective To analyze the differential expression of autophagy‐related genes of sepsis‐
induced acute respiratory distress syndrome (ARDS) as potential markers for early …

Novel application of nanomedicine for the treatment of acute lung injury: a literature review

X Chen, Z Tang - Therapeutic Advances in Respiratory …, 2024 - journals.sagepub.com
Nanoparticles have attracted extensive attention due to their high degree of cell targeting,
biocompatibility, controllable biological activity, and outstanding pharmacokinetics …

BMSCs mediates endothelial cell autophagy by upregulating miR‐155‐5p to alleviate ventilator‐induced lung injury

X Lin, T Yu, J Luo, L Chen, Y Liu, J Xu… - … of Biochemical and …, 2022 - Wiley Online Library
In this study, we explored to detect the effects and mechanism of bone‐marrow‐derived
mesenchymal stem cells (BMSCs) on ventilator‐induced lung injury (VILI). We transplanted …

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis

XP Wen, G Long, YZ Zhang, H Huang, TH Liu… - Proteome Science, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is characterized by refractory
hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell …

Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats

M Liu, J Liu, C Zhao, P Guo, Z Wang, H Wu… - BMC Pharmacology and …, 2023 - Springer
Objective Chlorine is a chemical threat agent that can be harmful to humans. Inhalation of
high levels of chlorine can lead to acute lung injury (ALI). Currently, there is no satisfactory …

Kukoamine A inhibits C‐C motif chemokine receptor 5 to attenuate lipopolysaccharide‐induced lung injury

X Liu, M Wang, Y Song, C Zhang… - Drug Development …, 2022 - Wiley Online Library
The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A
(KuA) treatment on endotoxin‐induced lung injury/inflammation. The study was performed in …

Dimethyl itaconate inhibits LPS-induced inflammatory release and apoptosis in alveolar type II epithelial and bronchial epithelial cells by activating pulmonary …

Y Shi, H Yin - Allergologia et Immunopathologia, 2022 - all-imm.com
Background: Injury to the lung is a common, clinically serious inflammatory disease.
However, its pathogenesis remains unclear, and the existing treatments, including cytokine …

GOLPH3 knockdown alleviates the inflammation and apoptosis in lipopolysaccharide-induced acute lung injury by inhibiting Golgi stress mediated autophagy

Y Wang, X Li, Q Zhou, S Zhang - Prostaglandins & Other Lipid Mediators, 2024 - Elsevier
Pneumonia, an acute inflammatory lesion of the lung, is the leading cause of death in
children aged< 5 years. We aimed to study the function and mechanism of Golgi …