Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Systemic administration of analgesics can lead to serious adverse side effects
compromising therapeutic benefit in some patients. Information coding pain transmits along …

The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine
(antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) …

Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was
evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the …

Spinal cord injury (SCI) results in abnormal locomotor and pain syndromes in humans. In a
rodent SCI model, T13 unilateral spinal hemisection results in bilateral mechanical allodynia …

The current study was designed to evaluate the transient antinociceptive interaction
between amitriptyline and paracetamol in the formalin test. In addition, considering other …

The role of allopregnanolone in the antinociceptive and antiallodynic effect of
palmitoylethanolamide has been addressed in two models of acute and persistent pain in …

Although it has been accepted that depression and pain are common comorbidities, their
interaction is not fully understood. The present study was aimed to investigate the effects of …

Stress activates multiple neural systems that suppress pain sensation. This adaptive
phenomenon referred as stress-induced analgesia (SIA) is mediated by the activation of …

Background The mechanism of action of paracetamol (acetaminophen) remains elusive
because it is still under discussion as to whether it acts locally and/or centrally. The primary …