Hereditary cancer syndromes result from germline genetic alterations predisposing
individuals to higher lifetime cancer risk than the general population. Hereditary cancer …

Screening for colorectal cancer (CRC) in Lynch syndrome enables early detection and likely
also cancer prevention. In this review, the term “screening”(also referred to as surveillance) …

Background Germline genetic testing enables primary cancer prevention, including through
prophylactic surgery. We examined risk‐reducing surgeries in unaffected individuals tested …

PURPOSE To develop an electronic health record (EHR)–based clinical decision support
(CDS) tool to promote guideline-recommended cancer risk management among patients …

Simple Summary The research is being suggested from the observation that the incidence of
colorectal cancer in individuals with Lynch Syndrome did not entirely decrease as expected …

Small bowel cancer (SBC) is the malignancy with the highest standardized incidence ratio in
Lynch syndrome (LS) patients. Of all SBCs, about 50% are duodenal cancers (DCs) …

Simple Summary Lynch syndrome (LS) is associated with varying cancer risks depending
on which of the five causative genes harbors a pathogenic variant; however, lifestyle and …

How could this be? The brilliant work from Heidelberg, Germany, identifying mismatch repair
deficient crypts in Lynch Syndrome, and the immunogenic nature of unstable micro-satellites …

Background Hereditary cancer syndromes cause a high lifetime risk of early, aggressive
cancers. Early recognition of individuals at risk can allow risk-reducing interventions that …

Abstract Background Lynch Syndrome is among the most common hereditary cancer
syndromes and requires ongoing cancer surveillance, repeated screenings and potential …