During our genomic era, the landscape of somatic mutations has been largely studied in
several types of carcinomas, producing evidences that the mutation spectra can be different …

The era of genomic revolution illustrated that cancer is a genetic disease where alterations
impair specific cellular pathways. For instance, cancer cells frequently physically remove cell …

DNA methylation is a fundamental epigenetic mechanism that is involved in long-term
programming of gene expression and in determining cell fate by regulating cell-specific …

1.1 Background of Refractory Non-small cell lung cancer 1.2 Rationale for the use of
Tetrahydrouridine-Decitabine in lung cancer 1.3 Mechanisms of immune-resistance in lung …

Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …

Platelets are small anucleate blood cells that are central to primary haemostasis. However,
platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells …

Le cancer du pancréas est un des cancers aux pronostics les plus sombres, avec une survie
à 5 ans inférieure à 10%. Associé à une incidence en hausse dans les pays développés, et …

Aim: Investigation of the influence of parthenolide (PTL) on cytarabine (Ara-C) action in an
acute promyelocytic leukemia HL-60 cell line and the role of oxidative stress in its action …

Significant progress has been made towards the development of phosphate prodrugs for
intracellular delivery of monophosphates. Such efforts led to the successful application of the …

Background: Conventional chemotherapy is still the main stay treatment for cancer, but its
efficacy is limited by its nonspecific drug distribution and lack of selectivity. Compared to …