Recent applications of immunomodulatory biomaterials for disease immunotherapy

H Dai, Q Fan, C Wang - Exploration, 2022 - Wiley Online Library
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …

Advances in extracellular vesicle nanotechnology for precision theranostics

Q Wu, S Fu, H Xiao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …

Engineered extracellular vesicles with SHP2 high expression promote mitophagy for Alzheimer's disease treatment

F Xu, Y Wu, Q Yang, Y Cheng, J Xu, Y Zhang… - Advanced …, 2022 - Wiley Online Library
Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD).
However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further …

[HTML][HTML] Oral feeding of nanoplastics affects brain function of mice by inducing macrophage IL-1 signal in the intestine

Q Yang, H Dai, Y Cheng, B Wang, J Xu, Y Zhang… - Cell Reports, 2023 - cell.com
Nanoplastics (NPs) as contaminants in food and water have drawn increasing public
attention. However, little is known about how NPs shape the gut immune landscape after …

Vesicular antibodies: shedding light on antibody therapeutics with cell membrane nanotechnology

C Zhao, Y Pan, G Yu, XZ Zhao, X Chen… - Advanced …, 2023 - Wiley Online Library
The high stability of antibodies and their ability to precisely bind to antigens and
endogenous immune receptors, as well as their susceptibility to protein engineering, enable …

[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

H Yao, F Wang, H Chong, J Wang, Y Bai… - Advanced …, 2023 - Wiley Online Library
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive
oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present …

Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

MicroRNAs in extracellular vesicles: sorting mechanisms, diagnostic value, isolation, and detection technology

D Xu, K Di, B Fan, J Wu, X Gu, Y Sun… - … in Bioengineering and …, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of short, single-stranded, noncoding RNAs, with a length
of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a …

Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation

S Wan, K Wang, P Huang, X Guo, W Liu, Y Li… - Nature …, 2024 - nature.com
Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases.
While the host immune cells do produce extracellular vesicles to counteract some …