Simple Summary In the fight against cancer, immunotherapies have given great hope after
encouraging results in clinical investigations showing complete remission in some patients …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, following strokes and cardiovascular diseases. Chronic lung inflammation is …

Induction of immune tolerance is the Holy Grail in transplantation medicine and
autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest …

Conventional CD4+ and CD8+ T lymphocytes comprise a mixture of naive and memory
cells. Generation and survival of these T-cell subsets is under strict homeostatic control and …

αβ T cells are critical components of the adaptive immune system and are capable of
inducing sterilizing immunity after pathogen infection and eliminating transformed tumor …

CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype
(MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like …

In conventional adaptive immune responses, upon recognition of foreign antigens, naive
CD4+ T lymphocytes are activated to differentiate into effector/memory cells. In addition …

The thymus produces self‐limiting and self‐tolerant T cells through the interaction between
thymocytes and thymus epithelial cells (TECs), thereby generating central immune …

FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both
the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to …