The broad field of gene therapy promises a number of innovative treatments that are likely to
become important in preventing deaths from cancer. In this review, we discuss the history …

Whether vaccines are designed to prepare the immune system for the encounter with a
pathogen or with cancer, certain common challenges need to be faced, such as what …

Despite tremendous progress in basic and epidemiological research, effective prevention of
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …

Purpose Our previous clinical experience with vaccinia and replication-defective avipox
recombinant carcinoembryonic antigen (CEA) vaccines has demonstrated safety and clinical …

The status of a host's immune response influences both the development and progression of
a malignancy such that immune responses can have both pro-and anti-tumorigenic effects …

Hereditary cancer syndromes (HCS) account for 5~ 10% of all cancer diagnosis. Lynch
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …

Background Different types of tumors have varying susceptibility to immunotherapy and
hence require different treatment strategies; these cover a spectrum ranging from 'hot'tumors …

Abstract CD4+ CD25+ Foxp3+ regulatory T (Treg) cells have been implicated in the lack of
effective antitumor immunity. Denileukin diftitox (DAB389IL-2), a fusion protein of interleukin …

Prevention or early detection is one of the most promising strategies against colorectal
cancer (CRC), the second leading cause of cancer death in the US. Recent studies indicate …

Reliable animal models are critical for evaluating immunotherapies and for defining tumor
immunology paradigms. Tumor immunologists are moving away from traditional …