Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …

Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …

In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and
carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of …

A one-pot two-step protocol was developed for the synthesis of a series of novel 4-
cyanamidobenzenesulfonamides from easily accessible methyl (4-sulfamoylphenyl) …

Acetylated triterpenoids betulin, oleanolic acid, ursolic acid, and glycyrrhetinic acid were
converted into their succinyl-spacered acetazolamide conjugates. These conjugates were …

A novel series of 2‐thioquinazoline‐benzenesulfonamide hybrids were designed as
carbonic anhydrase (CA) inhibitors. The design approach relies on molecular hybridization …

The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …

Aim: Human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are validated
antitumor/antimetastatic drug and tumor imaging targets with sulfonamide inhibitors and …

Extensive computer simulation studies have been carried out to probe the pH-dependent
structure and dynamics of the two most efficient isoenzymes II and IX of human carbonic …

Carbonic anhydrases (CAs; EC 4.2. 1.1) constitute a rather ancient class of enzymes that act
as highly efficient catalysts for the reversible hydration of CO2 to bicarbonate and protons …