Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

In mammals, the circadian clocks network (central and peripheral oscillators) controls
circadian rhythms and orchestrates the expression of a range of downstream genes …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …