[HTML][HTML] The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
AT Amare, KO Schubert, M Klingler-Hoffmann… - Translational …, 2017 - nature.com
Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …
studies have identified genetic variants associated with cardiovascular diseases, metabolic …
The genetics of circadian rhythms, sleep and health
A Jagannath, L Taylor, Z Wakaf… - Human molecular …, 2017 - academic.oup.com
Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …
clocks, which serve to coordinate internal time with the external world. The circadian system …
Melatonin—A pleiotropic, orchestrating regulator molecule
R Hardeland, DP Cardinali, V Srinivasan… - Progress in …, 2011 - Elsevier
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …
Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus
CA Vadnie, CA McClung - Neural plasticity, 2017 - Wiley Online Library
Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …
Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
Circadian regulation of depression: A role for serotonin
RA Daut, LK Fonken - Frontiers in neuroendocrinology, 2019 - Elsevier
Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …
Mitochondria, metabolism, and redox mechanisms in psychiatric disorders
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: a critical multi‐disciplinary literature review and agenda for future …
MJ McCarthy, JF Gottlieb, R Gonzalez… - Bipolar …, 2022 - Wiley Online Library
Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …
and appetite. Since many of these processes are regulated by circadian function, circadian …
[HTML][HTML] Clock genes and altered sleep–wake rhythms: their role in the development of psychiatric disorders
A Charrier, B Olliac, P Roubertoux… - International journal of …, 2017 - mdpi.com
In mammals, the circadian clocks network (central and peripheral oscillators) controls
circadian rhythms and orchestrates the expression of a range of downstream genes …
circadian rhythms and orchestrates the expression of a range of downstream genes …
[HTML][HTML] Melatonin in aging and disease—multiple consequences of reduced secretion, options and limits of treatment
R Hardeland - Aging and disease, 2012 - ncbi.nlm.nih.gov
Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …
physiological functions. Its secretion by the pineal gland progressively declines by age …