The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well
understood. Here, we show that diet-induced obesity (DIO) causes massive remodeling of …

The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian locomotor output
cycles protein kaput) was discovered in 1994 as a circadian clock. Soon after its discovery …

Circadian rhythms occur with a periodicity of approximately 24h and regulate a wide array of
metabolic and physiologic functions. Accumulating epidemiological and genetic evidence …

Background: Ezetimibe (SCH 58235) is a novel cholesterol absorption inhibitor that
selectively and potently blocks intestinal absorption of dietary and biliary cholesterol …

Background: Niacin and lovastatin are both effective drugs for the treatment of
hypercholesterolemia and are among the drugs of first choice recommended by the adult …

Since simvastatin is metabolised by the cytochrome P450 system, a potential for drug
interactions exists. Elevated HMG-CoA reductase inhibitory activity has been observed …