Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Radical surgery still represents the treatment choice for several malignancies. However,
local and distant tumor relapses remain the major causes of treatment failure, indicating that …

Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …

Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

The isolation or in vitro derivation of many human cell types remains challenging and
inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression …

Hematopoiesis in vertebrate embryos occurs in temporally and spatially overlapping waves
in close proximity to blood vascular endothelial cells. Initially, yolk sac hematopoiesis …

Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in
individuals with cancer; however, such factors have not yet been identified. Here we show …

The pathogenesis of Type 1 diabetes (T1D) arises from the destruction of insulin‐producing
β‐cells by islet‐specific autoreactive T cells. Inhibition of islet‐specific autoreactive T cells to …