Obesity is new in human evolutionary history, having become possible at the population
level with increased food security. Across the past 60 years, social, economic, and …

Syndecans (SDCs) are a family of heparan sulfate proteoglycans (HSPGs) glycoproteins
ubiquitously expressed on the cell surfaces and extracellular matrix of all mammalian …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Agouti-related protein (AGRP) plays a key role in energy homeostasis. The carboxyl-
terminal domain of AGRP acts as an endogenous antagonist of the melanocortin-4 receptor …

Hormonal responses to acute stress rely on the rapid induction of corticotropin-releasing
hormone (CRH) production in the mammalian hypothalamus, with subsequent instructive …

Agouti-related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on
melanocortin receptor (MC-R) signaling and energy balance, and are important targets for …

Social isolation is a powerful stressor capable of affecting brain plasticity and function. In the
case of breast cancer, previous data indicate that stressful experiences may contribute to a …

Taking a comparative approach, this book investigates the ways in which obesity and its
susceptibilities are framed in science and policy and how they might work better. Providing a …

Since nutrition-sensitive feedback signals normally act to maintain relatively stable levels of
both available and stored nutritional resources, failure in one or more of these feedback …

Debilitating muscle-disuse atrophy in aging or obesity has huge socioeconomic impact.
Since nitric oxide (NO) mediates muscle satellite cell activation and induces hypertrophy …