Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism

PH Finan, MT Smith - Sleep medicine reviews, 2013 - Elsevier
Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic
pain, and depression frequently co-occur and are mutually interacting conditions. However …

Altered brain iron homeostasis and dopaminergic function in restless legs syndrome (Willis–Ekbom disease)

CJ Earley, J Connor, D Garcia-Borreguero, P Jenner… - Sleep medicine, 2014 - Elsevier
Restless legs syndrome (RLS), also known as Willis–Ekbom Disease (WED), is a
sensorimotor disorder for which the exact pathophysiology remains unclear. Brain iron …

Restless legs syndrome: pathophysiology, clinical presentation and management

C Trenkwalder, W Paulus - Nature Reviews Neurology, 2010 - nature.com
Restless legs syndrome (RLS) is a somatosensory network disorder that is clinically
diagnosed according to four main criteria: an urge to move the legs, usually associated with …

The restless legs syndrome

C Trenkwalder, W Paulus, AS Walters - The lancet neurology, 2005 - thelancet.com
The restless legs syndrome is a common disorder that encompasses an idiopathic form of
genetic or unknown origin and symptomatic forms associated with many causes …

New insights into the neurobiology of restless legs syndrome

S Ferré, D García-Borreguero, RP Allen… - The …, 2019 - journals.sagepub.com
Restless legs syndrome (RLS) is a common sensorimotor disorder, whose basic
components include a sensory experience, akathisia, and a sleep-related motor sign …

International Continence Society consensus on the diagnosis and treatment of nocturia

K Everaert, F Hervé, R Bosch… - Neurourology and …, 2019 - Wiley Online Library
Introduction Patients with nocturia have to face many hurdles before being diagnosed and
treated properly. The aim of this paper is to: summarize the nocturia patient pathway, explore …

The treatment of sleep disorders in Parkinson's disease: from research to clinical practice

G Loddo, G Calandra-Buonaura, L Sambati… - Frontiers in …, 2017 - frontiersin.org
Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's
disease (PD), usually increasing in frequency over the course of the disease and disability …

Brain-iron deficiency models of restless legs syndrome

CJ Earley, BC Jones, S Ferré - Experimental neurology, 2022 - Elsevier
Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

Animal models of sleep disorders

LA Toth, P Bhargava - Comparative medicine, 2013 - ingentaconnect.com
Problems with sleep affect a large part of the general population, with more than half of all
people in the United States reporting difficulties with sleep or insufficient sleep at various …