Chiral switch: Between therapeutical benefit and marketing strategy

G Hancu, A Modroiu - Pharmaceuticals, 2022 - mdpi.com
Chirality of pharmaceutical substances is an important aspect in drug research because it
determines how enantiomers will interact with chiral biological targets. Enantiomers of a …

Chirality of new drug approvals (2013–2022): trends and perspectives

RU McVicker, NM O'Boyle - Journal of Medicinal Chemistry, 2024 - ACS Publications
Many drugs are chiral with their chirality determining their biological interactions, safety, and
efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer …

Tackling stereochemistry in drug molecules with vibrational optical activity

J Bogaerts, R Aerts, T Vermeyen, C Johannessen… - Pharmaceuticals, 2021 - mdpi.com
Chirality plays a crucial role in drug discovery and development. As a result, a significant
number of commercially available drugs are structurally dissymmetric and enantiomerically …

[HTML][HTML] Occurrence and adsorptive removal of sulfonamides and β-blockers in African and Asian water matrices: A comprehensive review

PP Mashile, TS Munonde, PN Nomngongo - Environmental Advances, 2023 - Elsevier
Pharmaceuticals in water bodies have led to severe water pollution, posing adverse human
and ecological health effects. These pollutants enter water bodies through various sources …

A Photoswitchable Ligand Targeting the β1‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm**

A Duran‐Corbera, M Faria, Y Ma… - Angewandte Chemie …, 2022 - Wiley Online Library
Catecholamine‐triggered β‐adrenoceptor (β‐AR) signaling is essential for the correct
functioning of the heart. Although both β1‐and β2‐AR subtypes are expressed in …

Chiral analysis of pharmaceuticals using NMR spectroscopy: A review

V Kumar Vashistha - Asian journal of organic chemistry, 2022 - Wiley Online Library
Chirality recognition of pharmaceutical products plays a significant part in asymmetric
synthesis, stereoselective catalysis, supramolecular chemistry, and the development of new …

Chirality of antidepressive drugs: an overview of stereoselectivity

VK Vashistha, S Sethi, I Tyagi, DK Das - Asian Biomedicine, 2022 - sciendo.com
Stereochemistry plays an important role in drug design because the enantiomers of a drug
frequently vary in their biological action and pharmacokinetic profiles. Racemates of a drug …

Detection and remediation of chiral pharmaceuticals from wastewater: A review

VK Vashistha - Chirality, 2022 - Wiley Online Library
Chiral organic pollutants including pharmaceuticals, pesticides, herbicides, flame retardants,
and polycyclic musk cause significant risks to both the environment and human health …

Stereoisomers in sports drug testing: analytical strategies and applications

A Thomas, M Thevis - Journal of Chromatography A, 2022 - Elsevier
Analytics employed in modern doping controls are designed to cover an extensive range of
rather diverse classes of substances, all of which are banned in sport according to the list of …

Visual chiral recognition of aromatic amino acids with (S)-mandelic acid-based ionic liquids via complexation

X Ma, Y Du, X Zhu, J Yang - Talanta, 2020 - Elsevier
Recently, chiral ionic liquids have attracted increasing attention in analytical chemistry.
However, only a few papers focus on the application of them in visual chiral recognition …