Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

During osteoarthritis (OA), angiogenesis is increased in the synovium, osteophytes and
menisci and leads to ossification in osteophytes and the deep layers of articular cartilage …

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the
articular cartilage, there is increasing body of data demonstrating the involvement of all …

Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis
remains poorly understood. OA is no longer considered a “wear and tear” condition but …

Objective In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA)
synovial tissue by training with gene expression data and machine learning. Methods …