Beyond the X factor: relevance of sex hormones in NAFLD pathophysiology

S Della Torre - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being
frequently associated with obesity, unbalanced dietary regimens, and reduced physical …

Sex as a Biological Variable in Cardiovascular Diseases: JACC Focus Seminar 1/7

JA Clayton, MD Gaugh - Journal of the American College of Cardiology, 2022 - jacc.org
Sex and gender influence all aspects of cardiovascular health and disease—including
epidemiology, pathophysiology, diagnosis, clinical manifestation, disease progression, and …

Sex in basic research: concepts in the cardiovascular field

R Ventura-Clapier, E Dworatzek… - Cardiovascular …, 2017 - academic.oup.com
Women and men, female and male animals and cells are biologically different, and
acknowledgement of this fact is critical to advancing medicine. However, incorporating …

[HTML][HTML] Current challenges surrounding exosome treatments

E Tzng, N Bayardo, PC Yang - Extracellular Vesicle, 2023 - Elsevier
Cardiovascular disease is the leading cause of death worldwide today and numerous
studies are demonstrating that exosomes improve cardiac function after myocardial injury …

Sex and age differences in AMPK phosphorylation, mitochondrial homeostasis, and inflammation in hearts from inflammatory cardiomyopathy patients

ML Barcena, G Tonini, N Haritonow, P Breiter… - Aging …, 2023 - Wiley Online Library
Linked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may
lead to dilated cardiomyopathy. Although sex and age differences in the development of …

Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease

A Kaur, ST Mackin, K Schlosser, FL Wong… - Cardiovascular …, 2020 - academic.oup.com
The aim of this systematic review was to assess dysregulated miRNA biomarkers in
coronary artery disease (CAD). Dysregulated microRNA (miRNAs) have been shown to be …

Estrogens, estrogen receptors effects on cardiac and skeletal muscle mitochondria

R Ventura-Clapier, J Piquereau, V Veksler… - Frontiers in …, 2019 - frontiersin.org
Mitochondria are unique organelles present in almost all cell types. They are involved not
only in the supply of energy to the host cell, but also in multiple biochemical and biological …

Sex-specific control of human heart maturation by the progesterone receptor

CB Sim, B Phipson, M Ziemann, H Rafehi, RJ Mills… - Circulation, 2021 - Am Heart Assoc
Background: Despite in-depth knowledge of the molecular mechanisms controlling
embryonic heart development, little is known about the signals governing postnatal …

Sex differences in cardiovascular actions of the renin–angiotensin system

D Medina, D Mehay, AC Arnold - Clinical Autonomic Research, 2020 - Springer
Cardiovascular disease (CVD) remains a worldwide public health concern despite decades
of research and the availability of numerous targeted therapies. While the intrinsic …

Widespread sex dimorphism in aging and age-related diseases

NK Sampathkumar, JI Bravo, Y Chen, PS Danthi… - Human genetics, 2020 - Springer
Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …