Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?

MN Gunning, B Fauser - Climacteric, 2017 - Taylor & Francis
To date, the world's leading cause of death amongst women is cardiovascular disease.
Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile …

Increases in circulating and fecal butyrate are associated with reduced blood pressure and hypertension: results from the SPIRIT trial

C Tilves, HC Yeh, N Maruthur… - Journal of the …, 2022 - Am Heart Assoc
Background Short chain fatty acids (SCFAs) are microbially derived end products of dietary
fiber fermentation. The SCFA butyrate reduces blood pressure (BP) in mouse models. The …

Sex in cardiovascular disease: Why this biological variable should be considered in in vitro models

AK McClain, PP Monteleone, J Zoldan - Science Advances, 2024 - science.org
Cardiovascular disease (CVD), the world's leading cause of death, exhibits notable
epidemiological, clinical, and pathophysiological differences between sexes. Many such …

Hormones and sex-specific medicine in human physiopathology

MR Tokatli, LG Sisti, E Marziali, L Nachira, MF Rossi… - Biomolecules, 2022 - mdpi.com
A prodigious increment of scientific evidence in both preclinical and clinical studies is
narrowing a major gap in knowledge regarding sex-specific biological responses observed …

Predominant role of nuclear versus membrane estrogen receptor α in arterial protection: implications for estrogen receptor α modulation in cardiovascular prevention …

E Guivarc'h, M Buscato, AL Guihot, J Favre… - Journal of the …, 2018 - Am Heart Assoc
Background Although estrogen receptor α (ER α) acts primarily as a transcription factor, it
can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic …

Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women: cross-sectional and longitudinal …

S Karvinen, MJ Jergenson, M Hyvärinen… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the primary cause of mortality in women in developed
countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that …

Lean body mass and the cardiovascular system constitute a female-specific relationship

C Diaz-Canestro, B Pentz, A Sehgal, R Yang… - Science Translational …, 2022 - science.org
Recent evidence points toward a link between lean body mass (LBM) and cardiovascular
capacity in women. This study aimed at determining the sex-specific relationship of LBM with …

Sex differences, genetic and environmental influences on dilated cardiomyopathy

A Jain, N Norton, KA Bruno, LT Cooper Jr… - Journal of clinical …, 2021 - mdpi.com
Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and
impaired systolic function and is the second most common cause of heart failure after …

Sex differences in eicosanoid formation and metabolism: a possible mediator of sex discrepancies in cardiovascular diseases

SH Gerges, AOS El-Kadi - Pharmacology & therapeutics, 2022 - Elsevier
Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …

Circadian rhythms in cardiovascular metabolism

H Lal, SK Verma, Y Wang, M Xie… - Circulation Research, 2024 - Am Heart Assoc
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …