An essential role for Hedgehog (Hh) signaling in human cancer has been established
beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO …

The past decade has seen significant advances in our understanding of Hedgehog (HH)
signaling pathway in various biological events. HH signaling pathway exerts its biological …

Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an
evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth …

Perineural invasion (PNI) is the process of neoplastic invasion of peripheral nerves and is
considered to be the fifth mode of cancer metastasis. PNI has been detected in head and …

Activation of Hedgehog (Hh) signaling is implicated in the development and progression of
several tumor types, including prostate cancer, which is still the most common non-skin …

Simple Summary Prostate cancer is one of the most frequently diagnosed cancers in men
worldwide. Perineural invasion (PNI), the movement of cancer cells along nerves, is a …

Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …

Prostate cancer (PCa) is the second most frequent cancer in men worldwide. NF-κB seems
to play a key role in cell survival, proliferation and invasion, sustaining the heterogeneous …

Background Dysregulation of hedgehog pathway is observed in numerous cancers.
Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream …

Simple Summary Molecular signatures predictive of recurrence-free survival (RFS) and
castration resistance are critical for treatment decision-making in prostate cancer (PCa), but …