Endothelial cells synthesize and release various factors that regulate angiogenesis,
inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The endothelium not only mediates relaxation but is a source of contracting factors.
Endothelium-dependent contractions are elicited by physical and chemical stimuli (ie …

Endothelial function deteriorates with aging. On the other hand, exercise training improves
the function of vascular endothelial cells. Endothelin-1 (ET-1), which is produced by vascular …

ET was initially isolated from a conditioned me-dium of the cultured porcine aortic
endothelial cells.'It consists of 21 amino acid residues including two intramolecular disulfide …

This review describes the ability of certain diseases, such as essential hypertension,
atherosclerosis, angina, and vasospasm, to reduce vascular nitric oxide (NO) formation or to …

We analyzed the effects and mechanisms of aging in aortic endothelium and vascular
smooth muscle of 12-week-old (adult) and 72-week-old (senescent) normotensive Wistar …

The endothelins are a family of 21–amino acid peptides that are powerful vasoconstrictors.
They may also induce vascular hypertrophy. These peptides may participate through these …

We have previously shown that the endothelin content in arteries of deoxycorticosterone
acetate (DOCA)-salt hypertensive rats is increased. We designed this study to examine …