Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control

MS Svetlov, CF Dunand, JA Nakamoto, GC Atkinson… - Molecular Cell, 2024 - cell.com
Rescuing stalled ribosomes often involves their splitting into subunits. In many bacteria, the
resultant large subunits bearing peptidyl-tRNAs are processed by the ribosome-associated …

Raising a Bacterium to the Rank of a Model System: The Listeria Paradigm

P Cossart - Annual Review of Microbiology, 2023 - annualreviews.org
My scientific career has resulted from key decisions and reorientations, sometimes taken
rapidly but not always, guided by discussions or collaborations with amazing individuals …

Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance

P Rudra, KR Hurst-Hess, KL Cotten… - Proceedings of the …, 2020 - National Acad Sciences
Antibiotic resistance in bacteria is typically conferred by proteins that function as efflux
pumps or enzymes that modify either the drug or the antibiotic target. Here we report an …

Association of Virulence, Biofilm, and Antimicrobial Resistance Genes with Specific Clonal Complex Types of Listeria monocytogenes

P Myintzaw, V Pennone, O McAuliffe, M Begley… - Microorganisms, 2023 - mdpi.com
Precise classification of foodborne pathogen Listeria monocytogenes is a necessity in
efficient foodborne disease surveillance, outbreak detection, and source tracking throughout …

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

X Hua, J He, J Wang, L Zhang, L Zhang… - Emerging Microbes & …, 2021 - Taylor & Francis
Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although
tigecycline currently remains a potent antibiotic for treating infections caused by multidrug …

Antibacterial phytocomplexes and compounds from Psychotria sycophylla (Rubiaceae) against drug-resistant bacteria

OMF Demgne, JFT Mbougnia, AJ Seukep… - Advances in Traditional …, 2022 - Springer
In this study, we examined the antibacterial and antibiotic-resistance reversal properties of
methanol (MeOH) and ethyl acetate (EtOAc) extracts and compounds from Psychotria …

The WblC/WhiB7 transcription factor controls intrinsic resistance to translation-targeting antibiotics by altering ribosome composition

JH Lee, JS Yoo, Y Kim, JS Kim, EJ Lee, JH Roe - MBio, 2020 - Am Soc Microbiol
Bacteria that encounter antibiotics can efficiently change their physiology to develop
resistance. This intrinsic antibiotic resistance is mediated by multiple pathways, including a …

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

Y Halfon, A Jimenez-Fernandez… - Proceedings of the …, 2019 - National Acad Sciences
Resistance to antibiotics has become a major threat to modern medicine. The ribosome
plays a fundamental role in cell vitality by the translation of the genetic code into proteins; …

Innovative strategies to overcome antimicrobial resistance and tolerance

MI Choudhary, U Römling, F Nadeem, HM Bilal… - Microorganisms, 2022 - mdpi.com
Antimicrobial resistance and tolerance are natural phenomena that arose due to
evolutionary adaptation of microorganisms against various xenobiotic agents. These …

Bacterial drug efflux pump inhibitors from plants

AJ Seukep, CD Fokoua-Maxime, HG Mbuntcha… - Antimicrobial Resistance …, 2022 - Springer
The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health,
food security, and development. Drug-resistant pathogens diminish the effectiveness of …