Metabolic studies of mammalian embryos started with the development of in vitro culture
systems more than 40 years ago. More recently, metabolic studies have begun to shed light …

Oocyte intracellular lipids are mainly stored in lipid droplets (LD) providing energy for proper
growth and development. Lipids are also important signalling molecules involved in the …

High-resolution molecular programmes delineating the cellular foundations of mammalian
embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre …

This study aimed to investigate the use of Nile red, a fluorescent dye specific for intracellular
lipid droplets, to quantify the lipid content of single mammalian oocytes. It was hypothesized …

Mammalian pre-implantation development culminates in the formation of the blastocyst
consisting of two distinct cell lineages, approximately a third of the cells comprise the …

The role of endogenous lipid in the provision of energy during in vitro maturation of
immature porcine oocytes has been studied. Fluorescence resonance energy transfer …

BACKGROUND Assisted reproduction technology offers the opportunity to observe the very
early stages of human development. However, due to practical constraints, for decades …

Here, we have investigated mitochondrial biology and energy metabolism in human
embryonic stem cells (hESCs) and hESC-derived neural stem cells (NSCs). Although stem …

Fatty acids are not only widely known as energy sources, but also play important roles in
many metabolic pathways. The significance of fatty acids in modulating the reproductive …

Mitochondria play a primary role in cellular energetic metabolism, homeostasis, and death.
They possess their own multicopy genome, which is maternally transmitted. Mitochondria …