Rapid advances in high-throughput genomic technology have enabled biology to enter the
era of 'Big Data'(large datasets). The plant science community not only needs to build its …

Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …

Motivation Understanding the relationship between the sequence, structure, binding energy,
binding kinetics and binding thermodynamics of protein–protein interactions is crucial to …

Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein
complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on …

The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic
secretagogues and neurokinins. A number of commonly used small-molecule drugs (eg …

Genome-wide association studies of human personality have been carried out, but
transcription of the whole genome has not been studied in relation to personality in humans …

Translating data to knowledge and actionable insights is the Holy Grail for many scientific
fields, including biology. The unprecedented massive and heterogeneous data have created …

Single-nucleotide polymorphisms (SNPs) are single-base variants that contribute to human
biological variation and pathogenesis of many human diseases. Among all SNP types …

Differentiation between phenotypically neutral and disease-causing genetic variation
remains an open and relevant problem. Among different types of variation, non-frameshifting …

Autophagy, an evolutionary conserved multifaceted lysosome-mediated bulk degradation
system, plays a vital role in liver pathologies including hepatocellular carcinoma (HCC). Post …