Vaccines are the cornerstone of infectious disease control and prevention. The outbreak of
SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel …

Plants are increasingly used for the production of high-quality biological molecules for use
as pharmaceuticals and biomaterials in industry. Plants have proved that they can produce …

As a type of immunogenic cell death, ferroptosis participates in the creation of immunoactive
tumor microenvironments. However, knowledge of spatial location of tumor cells with …

The lack of optimal models to evaluate novel agents is delaying the development of effective
immunotherapies against human breast cancer (BC). In this prospective open label study …

Our lab demonstrated that intratumoral Cowpea mosaic virus (CPMV) is a potent antitumor
immunotherapy when used as in situ vaccine. As we pave the way for human clinical …

Ovarian cancer (OvCa) is a leading cause of mortality among gynecological malignancies
and usually manifests as intraperitoneal spheroids that generate metastases, ascites, and …

Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising
nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and …

Due to the increasing incidence of cancer, there is a need to develop new platforms that can
combat this disease. Cancer immunotherapy is a platform that takes advantage of the …

Plant virus nanoparticles can be used as drug carriers, imaging reagents, vaccine carriers,
and immune adjuvants in the formulation of intratumoral in situ cancer vaccines. One …

Cowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy
as an intratumoral immunotherapy, providing a strong argument for its clinical translation …