Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential
strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic …

Although various drug delivery systems that regulated Ca 2+ concentration has been
developed for tumor therapy, their application still presented significant challenges due to …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

Abstract Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for
oncological application as a repurposed drug. We show here that 4~ 5 µM AF induces …

Paraptosis is a type of programmed cell death that is characterized by dilation of the
endoplasmic reticulum (ER) and/or mitochondria. Since paraptosis is morphologically and …

The endoplasmic reticulum (ER) comprises a network of tubules and vesicles that
constitutes the largest organelle of the eukaryotic cell. Being the location where most …

Calcium channel upregulation has been implicated in cancer cell proliferation and
progression including in breast cancer. Fortunately, the function of calcium channels can be …

Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

Pyroptosis has garnered increasing attention because of its ability to trigger robust antitumor
immunity. Pyroptosis is initiated by the activation of inflammasomes, which are regulated by …