Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review

CR Bain, PS Myles, T Corcoran, JM Dieleman - Anaesthesia, 2023 - Wiley Online Library
In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …

Dexamethasone and surgical-site infection

TB Corcoran, PS Myles, AB Forbes… - … England Journal of …, 2021 - Mass Medical Soc
Background The glucocorticoid dexamethasone prevents nausea and vomiting after
surgery, but there is concern that it may increase the risk of surgical-site infection. Methods …

Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial

K Asehnoune, C Le Moal, G Lebuffe, M Le Penndu… - bmj, 2021 - bmj.com
Objective To assess the effect of dexamethasone on complications or all cause mortality
after major non-cardiac surgery. Design Phase III, randomised, double blind, placebo …

[HTML][HTML] The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis

QY Pang, JY Wang, XL Liang, Y Jiang, HL Liu - Perioperative Medicine, 2023 - Springer
Background Dexamethasone is commonly used for antiemesis in surgical patients. It has
been confirmed that long-term steroid use increases blood glucose level in both diabetic …

Perioperative dexamethasone administration does not increase the incidence of postoperative infection in total hip and knee arthroplasty: a retrospective analysis

AB Richardson, A Bala, SS Wellman, DE Attarian… - The Journal of …, 2016 - Elsevier
Background Dexamethasone is frequently used for the treatment of postoperative nausea
and vomiting and as an adjunct in multimodal postoperative analgesia after total joint …

Perioperative ADministration of Dexamethasone And blood Glucose concentrations in patients undergoing elective non-cardiac surgery–the randomised controlled …

TB Corcoran, E O'Loughlin, MTV Chan… - European Journal of …, 2021 - journals.lww.com
Perioperative ADministration of Dexamethasone And blood Gluc... : European Journal of
Anaesthesiology | EJA Perioperative ADministration of Dexamethasone And blood Glucose …

[HTML][HTML] Dexamethasone and clinically significant postoperative nausea and vomiting: a prespecified substudy of the randomised perioperative administration of …

TB Corcoran, C Martin, E O'Loughlin, KM Ho… - British Journal of …, 2022 - Elsevier
Background Clinically significant postoperative nausea and vomiting (PONV) is a patient-
reported outcome which reflects patient experience. Although dexamethasone prevents …

Intraoperative dexamethasone does not increase the risk of postoperative wound infection: a propensity score-matched post hoc analysis of the ENIGMA-II trial …

T Corcoran, J Kasza, TG Short… - BJA: British Journal …, 2017 - academic.oup.com
Background. In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether
intraoperative dexamethasone was associated with adverse safety outcomes. Methods …

Antiemetic doses of dexamethasone and their effects on immune cell populations and plasma mediators of inflammation resolution in healthy volunteers

A Barden, M Phillips, LM Hill, EM Fletcher… - … and essential fatty acids, 2018 - Elsevier
Introduction The synthetic glucocorticoid dexamethasone is a commonly administered
antiemetic. It has immunosuppressive effects and may alter postoperative blood glucose …

A survey of anaesthetists' use of tranexamic acid in noncardiac surgery

TW Painter, D McIlroy, PS Myles… - … and Intensive Care, 2019 - journals.sagepub.com
Major bleeding in noncardiac surgery is common and associated with serious complications.
The antifibrinolytic agent tranexamic acid (TXA) reduces bleeding and may reduce the risk of …