The combination of spatial transcriptomics (ST) and single cell RNA sequencing (scRNA-
seq) acts as a pivotal component to bridge the pathological phenomes of human tissues with …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …

Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities
and functions of the different BM stromal elements in humans remain poorly defined. Based …

The metabolic, digestive and homeostatic roles of the liver are dependent on proper
crosstalk and organization of hepatic cell lineages. These hepatic cell lineages are derived …

Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our
understanding of intricate tissue architectures. However, this rapidly expanding field …

In adult mammalian bone marrow (BM), vascular endothelial cells and perivascular reticular
cells control the function of haematopoietic stem and progenitor cells (HSPCs). During fetal …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …

Background Extravillous trophoblast cell (EVT) differentiation and its communication with
maternal decidua especially the leading immune cell type natural killer (NK) cell are critical …

Demand-adjusted and cell type specific rates of protein synthesis represent an important
safeguard for fate and function of long-term hematopoietic stem cells. Here, we identify …