[HTML][HTML] New understanding of the relevant role of LINE-1 retrotransposition in human disease and immune modulation

X Zhang, R Zhang, J Yu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …

Multi-omics molecular biomarkers and database of osteoarthritis

J Li, X Yang, Q Chu, L Xie, Y Ding, X Xu, MP Timko… - Database, 2022 - academic.oup.com
Osteoarthritis (OA) is the most common form of arthritis in the adult population and is a
leading cause of disability. OA-related genetic loci may play an important role in clinical …

[HTML][HTML] Anemia and formation of deep vein thrombosis before operation in patients with knee osteoarthritis: a cross-sectional study

X Xiong, T Li, B Cheng - Journal of Orthopaedic Surgery and Research, 2023 - Springer
Background Preoperative anemia is a common complication in knee osteoarthritis (KOA)
patients. However, the association between anemia and preoperative deep vein thrombosis …

[HTML][HTML] Telomere shortening is associated with poor physical performance in knee osteoarthritis

P Manoy, P Yuktanandana… - Biomedical …, 2020 - spandidos-publications.com
Telomere length is a hallmark characteristic of ageing and age‑related diseases.
Osteoarthritis (OA) is the most common cause of joint pain and physical disability in the …

[HTML][HTML] Potential methods of targeting cellular aging hallmarks to reverse osteoarthritic phenotype of chondrocytes

Y He, KE Lipa, PG Alexander, KL Clark, H Lin - Biology, 2022 - mdpi.com
Simple Summary Osteoarthritis (OA) is the most common chronic and disabling joint disease
worldwide, causing pain and impaired mobility. Currently, no effective disease-modifying …

Mitochondrial dsRNAs activate PKR and TLR3 to promote chondrocyte degeneration in osteoarthritis

S Kim, K Lee, YS Choi, J Ku, YJ Lee, Y Kim - BioRxiv, 2020 - biorxiv.org
Protein kinase R (PKR) is an immune response protein that becomes activated by long
double-stranded RNAs (dsRNAs). Several studies reported the misactivation of PKR in …

Developing New Pharmacological Tools to Modulate Transposable Elements' Activity in Colorectal Cancer

A Mendes da Silva - 2023 - ruor.uottawa.ca
LINE-1 retrotransposons, also known as" jumping genes", are repetitive sequences capable
of copying, pasting, and reinserting themselves into the genome. These events were …

Drug Repurposing Patent Applications October–December 2019

HAM Mucke - ASSAY and Drug Development Technologies, 2020 - liebertpub.com
To reduce nitrogen uptake by body tissues, which would otherwise require extensive
decompression times during surfacing to avoid the painful ''bends''and nitrogen narcosis …

[引用][C] DNA-Methylierung als potentieller Biomarker in der Differentialdiagnose von Peritonitis und Peritonealkarzinose im Aszites

K Bose - 2022 - Dissertation, Magdeburg, Otto-von …