The effects of hypoxia on the human organism has been considered doubly fascinating by
the scientific community. The knowledge of the discrete mechanisms allowing the …

The current pandemic of surgical complications necessitates urgent and pragmatic
innovation to reduce postoperative morbidity and mortality, which are associated with poor …

BACKGROUND: Hypoxia-induced elevation in pulmonary artery pressure during air travel
may contribute to the worldwide burden of in-flight medical emergencies. The pulmonary …

Hypoxia causes an increase in pulmonary artery pressure. Gene expression controlled by
the hypoxia‐inducible factor (HIF) family of transcription factors plays an important role in the …

BACKGROUND: Members of the public will soon be taking commercial suborbital
spaceflights with significant Gx (chest-to-back) acceleration potentially reaching up to 6 Gx …

Fewer than 600 people have been to space, mostly very fit and healthy professional
astronauts who have undergone careful medical screening and selection, but this is about to …

Oxygen‐dependent regulation of the erythropoietin gene is mediated by the hypoxia‐
inducible factor (HIF) family of transcription factors. When oxygen is plentiful, HIF undergoes …

BACKGROUND: High-G acceleration experienced during launch and re-entry of suborbital
spaceflights may present challenges for older or medically susceptible participants. A …

The purpose of the study is to understand the effect of altitude on the performance of
selected pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). A …

Future spacecraft and crew habitats are anticipated to use a moderately hypobaric and
hypoxic cabin atmosphere to reduce the risk of decompression sickness associated with …