The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Kisspeptin is involved in the control of human reproduction bridging the gap between the
sex steroid levels and feedback mechanisms that control the gonadotropin releasing …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

Women's health disorders such as uterine fibroids and endometriosis are currently treated
by GnRH modulators that effectively suppress the hypothalamic-pituitary-gonadal axis. The …

BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology
remains uncertain. Whereas kisspeptins, the products of Kiss1 that act via Kiss1r (aka …

Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and
insulin resistance. There is a growing body of evidence indicating that adiponectin has …