Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Clinical trials in Wilms tumor (WT) have resulted in overall survival rates of greater than 90%.
This achievement is especially remarkable because improvements in disease-specific …

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …

Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is
associated with adverse prognosis. To uncover the underlying tumor biology and find …

We report the most common single-nucleotide substitution/deletion mutations in favorable
histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA …

Objective: The Children's Oncology Group study AREN0534 aimed to improve event-free
survival (EFS) and overall survival (OS) while preserving renal tissue by intensifying …

Most children with tumors will require one or more surgical interventions as part of the care
and treatment, including making a diagnosis, obtaining adequate venous access …

Wilms tumor is the most common pediatric renal tumor, accounting for approximately 7% of
all childhood cancers. Imaging plays an important role in the detection, staging, post-therapy …

With the development of RNA modification research, the importance of N6-methyladenosine
(m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and …

Simple Summary A Wilms tumor is a childhood kidney tumor. In high-income countries, 90%
of patients with this tumor survive. However, the tumor recurs in 15% of patients. It is …