Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

Human exposure to environmental arsenic induces cardiovascular diseases such as
arrhythmias, hypertension, and arteriosclerosis. Here, we review the toxicological and …

Pharmaceutical companies operate in a strictly regulated and highly risky environment in
which a single slip can lead to serious financial implications. Accordingly, the …

Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the
uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the …

Background Diabetic kidney disease (DKD), as a serious microvascular complication of
diabetes, has limted treatment options. It is reported that the Sacubitril/Valsartan (Sac/Val) …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Fibroblasts are essential regulators of extracellular matrix deposition following cardiac
injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response …

Background and Purpose Pathological cardiomyocyte hypertrophy is a response to cardiac
stress that typically leads to heart failure. Despite being a primary contributor to pathological …

Over the past several decades, mathematical modeling has been applied to increasingly
wider scopes of questions in drug development. Accordingly, the range of modeling tools …