[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Haemostatically active proteins in snake venoms

T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of …

D Pla, L Sanz, S Quesada-Bernat, M Villalta, J Baal… - Journal of …, 2019 - Elsevier
Russell's viper (Daboia russelii) is, together with Naja naja, Bungarus caeruleus and Echis
carinatus, a member of the medically important 'Big Four'species responsible for causing a …

Venom proteomics and antivenom neutralization for the Chinese eastern Russell's viper, Daboia siamensis from Guangxi and Taiwan

KY Tan, NH Tan, CH Tan - Scientific reports, 2018 - nature.com
The eastern Russell's viper (Daboia siamensis) causes primarily hemotoxic envenomation.
Applying shotgun proteomic approach, the present study unveiled the protein complexity …

New generation of drug delivery systems based on ginsenoside Rh2-, Lysine-and Arginine-treated highly porous graphene for improving anticancer activity

H Zare-Zardini, A Taheri-Kafrani, A Amiri… - Scientific reports, 2018 - nature.com
In this study, Rh2–treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene
(Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2–treated Gr-Lys (Gr-Lys-Rh2) and Rh2–treated Gr …

Advances in the therapeutic application of small-molecule inhibitors and repurposed drugs against snakebite: Miniperspective

U Puzari, PA Fernandes… - Journal of Medicinal …, 2021 - ACS Publications
The World Health Organization has declared snakebite as a neglected tropical disease.
Antivenom administration is the sole therapy against venomous snakebite; however, several …

[HTML][HTML] Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles)

D Trevisan-Silva, LH Gremski, OM Chaim… - Biochimie, 2010 - Elsevier
Brown spiders have a worldwide distribution, and their venom has a complex composition
containing many different molecules. Herein, we report the existence of a family of astacin …

Unveiling the complexities of Daboia russelii venom, a medically important snake of India, by tandem mass spectrometry

M Sharma, D Das, JK Iyer, RM Kini, R Doley - Toxicon, 2015 - Elsevier
Abstract Composition of Indian Russell's viper (Daboia russelii russelii) venom, a medically
important snake and member of “Big Four” snakes of India was done by gel filtration …

Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes

AK Tashima, A Zelanis, ES Kitano, D Ianzer… - Molecular & cellular …, 2012 - ASBMB
Snake venom proteomes/peptidomes are highly complex and maintenance of their integrity
within the gland lumen is crucial for the expression of toxin activities. There has been …

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces …

DE Vivas-Ruiz, P Rosas, A Proleón, D Torrejón, F Lazo… - Pharmaceutics, 2023 - mdpi.com
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently
have described toxins that inhibited platelet aggregation and cancer cell migration. In this …