Real-world evidence of dupilumab efficacy and risk of adverse events: a systematic review and meta-analysis

AS Halling, N Loft, JI Silverberg… - Journal of the American …, 2021 - Elsevier
Background Dupilumab, the first biological drug to be approved for the treatment of
moderate to severe atopic dermatitis in adolescents and adults, has shown good efficacy …

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

[HTML][HTML] T helper 2 IL-4/IL-13 dual blockade with dupilumab is linked to some emergent T helper 17‒type diseases, including seronegative arthritis and enthesitis …

C Bridgewood, M Wittmann, T Macleod, A Watad… - Journal of Investigative …, 2022 - Elsevier
Dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent seronegative
inflammatory arthritis and psoriasis that form part of the spondyloarthropathy spectrum. We …

Rituximab, omalizumab, and dupilumab treatment outcomes in bullous pemphigoid: a systematic review

P Cao, W Xu, L Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal
bullous disease of the skin. First-line treatment of systemic corticosteroids may cause …

Molecular targets for biological therapies of severe asthma

C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …

European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period

C Vestergaard, A Wollenberg… - Journal of the …, 2019 - Wiley Online Library
Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and
adults, including a large number of adults of reproductive age. Several guidelines for the …

[HTML][HTML] Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective

C Hemrajani, P Negi, A Parashar, G Gupta… - Biomedicine & …, 2022 - Elsevier
Atopic dermatitis (AD) is an inflammatory disorder centered around loss of epidermal barrier
function, and T helper 2 (Th2) immune responses. The current understanding of disease …

[HTML][HTML] Janus kinase inhibitors for the treatment of atopic dermatitis: focus on abrocitinib, baricitinib, and upadacitinib

M Nogueira, T Torres - Dermatology Practical & Conceptual, 2021 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is a clinically heterogenous, inflammatory skin condition with a high
impact on patients' daily activities that remains difficult to treat. The knowledge acquired over …

Overview of atopic dermatitis in different ethnic groups

A Chiricozzi, M Maurelli, L Calabrese, K Peris… - Journal of Clinical …, 2023 - mdpi.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high
prevalence worldwide, including countries from Asia, Africa, and Latin America, and in …

Emerging role of janus kinase inhibitors for the treatment of atopic dermatitis

R Singh, CE Heron, RI Ghamrawi… - ImmunoTargets and …, 2020 - Taylor & Francis
Background Atopic dermatitis (AD) is a common chronic, inflammatory skin condition. The
pathogenesis of AD involves many cytokines that utilize the Janus kinase/signal transducer …