Mammary cancer is one of the most common cancers, victimizing more than half a million of
women worldwide every year. Despite all the studies in this field, the current therapeutic …

Breast cancer is the most frequent spontaneous malignancy diagnosed in women and is
characterized by a broad histological diversity. Progression of the disease has a …

We describe here a detailed protocol for generating gene knockout rats by homologous
recombination in embryonic stem (ES) cells. This protocol comprises the following …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Mammary organoid (MaO) models are only available for a few traditional model organisms,
limiting our ability to investigate mammary gland development and cancer across mammals …

Women who are heterozygous for deleterious BRCA1 germline mutations harbor a high risk
of hereditary breast cancer. Previous Brca1‐heterozygous animal models do not …

Crystal structures exist for human, but not rodent, estrogen receptor-α ligand-binding domain
(ERα-LBD). Consequently, rodent studies involving binding of compounds to ERα-LBD are …

The ability to “knockout” specific genes in mice via embryonic stem (ES) cell-based gene-
targeting technology has significantly enriched our understanding of gene function in normal …

Rat has been the major model species used in several biomedical fields, notably in drug
development and toxicology, including carcinogenicity testing. Rat is also a useful model in …

We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-
Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer …