[HTML][HTML] The Impact of Microglia on Neurodevelopment and Brain Function in Autism

Y Luo, Z Wang - Biomedicines, 2024 - mdpi.com
Microglia, as one of the main types of glial cells in the central nervous system (CNS), are
widely distributed throughout the brain and spinal cord. The normal number and function of …

[HTML][HTML] Autism Spectrum Disorder: Brain Areas Involved, Neurobiological Mechanisms, Diagnoses and Therapies

J Lamanna, J Meldolesi - International Journal of Molecular Sciences, 2024 - mdpi.com
Autism spectrum disorder (ASD), affecting over 2% of the pre-school children population,
includes an important fraction of the conditions accounting for the heterogeneity of autism …

The Notch1/Hes1 pathway regulates Neuregulin 1/ErbB4 and participates in microglial activation in rats with VPA-induced autism

Y Deng, L Ma, Z Du, H Ma, Y Xia, L Ping, Z Chen… - Progress in Neuro …, 2024 - Elsevier
The core clinical characteristics of autism, which is a neurodevelopmental disease, involve
repetitive behavior and impaired social interactions. Studies have shown that the Notch and …

Microglial Dysfunction in Autism Spectrum Disorder

J Meng, L Zhang, Y Zhang - The Neuroscientist, 2024 - journals.sagepub.com
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder
with onset in childhood. The molecular mechanisms underlying ASD have not yet been …

An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period

L Rogerson‐Wood, CS Goldsbury, A Sawatari… - Glia, 2024 - Wiley Online Library
Brain function is critically dependent on correct circuit assembly. Microglia are well‐known
for their important roles in immunological defense and neural plasticity, but whether they can …

Emerging drugs for the treatment of irritability associated with autism spectrum disorder

A Shamabadi, H Karimi… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of
1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a …

Neuroplasticity of children in autism spectrum disorder

Z Chen, X Wang, S Zhang, F Han - Frontiers in Psychiatry, 2024 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that encompasses a
range of symptoms including difficulties in verbal communication, social interaction, limited …

Early pyridoxine administration rescues autism-like behavior in the BTBR T+ tf/J autistic model

R Ruan, W Shao, Y Su, J Liu, J Luo, Y Luo… - Research in Autism …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by social impairment and repetitive, stereotyped behaviors. An imbalanced oxidative stress …

[HTML][HTML] Microglial Dyshomeostasis: A Common Substrate in Neurodevelopmental and Neurodegenerative Diseases

VA Furlan, D MacAuslan, K Ha, N Patel, S Adam… - Neuroglia, 2024 - mdpi.com
Neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit
hyperactivity disorder (ADHD) are clinically distinct, yet share synaptic dysfunction as a …

Exploring the Dynamics of Social Interactions During the Juvenile Stage in a Mouse Model of Fragile X Syndrome

MY Bae, B Wang, A Abdullah, A Ahmed, R Ilyas… - bioRxiv, 2024 - biorxiv.org
Introduction: Fragile X Syndrome (FXS), caused by mutations in the Fmr1 gene, is a
neurodevelopmental condition linked to cognitive and behavioral differences, including …