[HTML][HTML] Plant-derived natural products for drug discovery: current approaches and prospects
N Nasim, IS Sandeep, S Mohanty - The Nucleus, 2022 - Springer
Nature has abundant source of drugs that need to be identified/purified for use as essential
biologics, either individually or in combination in the modern medical field. These drugs are …
biologics, either individually or in combination in the modern medical field. These drugs are …
[HTML][HTML] Capsaicin: A potential treatment to improve cerebrovascular function and cognition in obesity and ageing
T Thornton, D Mills, E Bliss - Nutrients, 2023 - mdpi.com
Impaired cognition is the primary symptom of dementia, which can lead to functional
disability and reduced quality of life among an increasingly ageing population. Ageing is …
disability and reduced quality of life among an increasingly ageing population. Ageing is …
[HTML][HTML] ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention
D Cabañero, E Villalba-Riquelme… - Pharmacology & …, 2022 - Elsevier
Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …
Capsaicin improves hypertension and cardiac hypertrophy via SIRT1/NF-κB/MAPKs pathway in the hypothalamic paraventricular nucleus
XY Jia, DL Jiang, XT Jia, LY Fu, H Tian, KL Liu, J Qi… - Phytomedicine, 2023 - Elsevier
Background Hypertension has seriously affected a large part of the adult and elderly
population. The complications caused by hypertension are important risk factors for …
population. The complications caused by hypertension are important risk factors for …
Alzheimer, Parkinson, dementia, and phytochemicals: insight review
Abstract Alzheimer's, Parkinson's, and dementia are the leading neurodegenerative
diseases that threaten the world with the aging population. Although the pathophysiology of …
diseases that threaten the world with the aging population. Although the pathophysiology of …
Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats
Excitotoxicity and neuroinflammation are key contributors to perinatal brain injuries.
Capsaicin, an active ingredient of chili peppers, is a potent exogenous agonist for transient …
Capsaicin, an active ingredient of chili peppers, is a potent exogenous agonist for transient …
Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage
CE Edmonds, RZ German, LE Bond… - Journal of …, 2022 - journals.physiology.org
Sensorimotor feedback is critical to safe and effective swallowing. Because of this, sensory
interventions have the potential to treat dysphagia. One such treatment may be found in …
interventions have the potential to treat dysphagia. One such treatment may be found in …
Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression
A Mondal, S Banerjee, W Terang… - Phytotherapy …, 2024 - Wiley Online Library
Cancer profoundly influences morbidity and fatality rates worldwide. Patients often have
dismal prognoses despite recent improvements in cancer therapy regimens. However …
dismal prognoses despite recent improvements in cancer therapy regimens. However …
[HTML][HTML] Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases
W Wang, T Sun - Molecules, 2023 - mdpi.com
Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective
cation channel protein, which can be activated by various physical and chemical stimuli …
cation channel protein, which can be activated by various physical and chemical stimuli …
Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus
XY Jia, Y Yang, XT Jia, DL Jiang, LY Fu… - Frontiers in …, 2024 - frontiersin.org
Background Long term hypertension seriously promotes target organ damage in the brain
and heart, and has increasingly become serious public health problem worldwide. The anti …
and heart, and has increasingly become serious public health problem worldwide. The anti …