[HTML][HTML] Plant-derived natural products for drug discovery: current approaches and prospects

N Nasim, IS Sandeep, S Mohanty - The Nucleus, 2022 - Springer
Nature has abundant source of drugs that need to be identified/purified for use as essential
biologics, either individually or in combination in the modern medical field. These drugs are …

[HTML][HTML] Capsaicin: A potential treatment to improve cerebrovascular function and cognition in obesity and ageing

T Thornton, D Mills, E Bliss - Nutrients, 2023 - mdpi.com
Impaired cognition is the primary symptom of dementia, which can lead to functional
disability and reduced quality of life among an increasingly ageing population. Ageing is …

[HTML][HTML] ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention

D Cabañero, E Villalba-Riquelme… - Pharmacology & …, 2022 - Elsevier
Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …

Capsaicin improves hypertension and cardiac hypertrophy via SIRT1/NF-κB/MAPKs pathway in the hypothalamic paraventricular nucleus

XY Jia, DL Jiang, XT Jia, LY Fu, H Tian, KL Liu, J Qi… - Phytomedicine, 2023 - Elsevier
Background Hypertension has seriously affected a large part of the adult and elderly
population. The complications caused by hypertension are important risk factors for …

Alzheimer, Parkinson, dementia, and phytochemicals: insight review

B Can, N Sanlier - Critical reviews in food science and nutrition, 2023 - Taylor & Francis
Abstract Alzheimer's, Parkinson's, and dementia are the leading neurodegenerative
diseases that threaten the world with the aging population. Although the pathophysiology of …

Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats

YB Kilinc, M Dilek, E Kilinc, IE Torun, A Saylan… - Chemico-Biological …, 2023 - Elsevier
Excitotoxicity and neuroinflammation are key contributors to perinatal brain injuries.
Capsaicin, an active ingredient of chili peppers, is a potent exogenous agonist for transient …

Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage

CE Edmonds, RZ German, LE Bond… - Journal of …, 2022 - journals.physiology.org
Sensorimotor feedback is critical to safe and effective swallowing. Because of this, sensory
interventions have the potential to treat dysphagia. One such treatment may be found in …

Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

A Mondal, S Banerjee, W Terang… - Phytotherapy …, 2024 - Wiley Online Library
Cancer profoundly influences morbidity and fatality rates worldwide. Patients often have
dismal prognoses despite recent improvements in cancer therapy regimens. However …

[HTML][HTML] Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases

W Wang, T Sun - Molecules, 2023 - mdpi.com
Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective
cation channel protein, which can be activated by various physical and chemical stimuli …

Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus

XY Jia, Y Yang, XT Jia, DL Jiang, LY Fu… - Frontiers in …, 2024 - frontiersin.org
Background Long term hypertension seriously promotes target organ damage in the brain
and heart, and has increasingly become serious public health problem worldwide. The anti …