Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon - Trends in Microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be …

Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Gut microbially produced indole-3-propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to …

H Xue, X Chen, C Yu, Y Deng, Y Zhang… - Circulation …, 2022 - Am Heart Assoc
Background: Accumulating evidence has shown that disorders in the gut microbiota and
derived metabolites affect the development of atherosclerotic cardiovascular disease …

The protective role of butyrate against obesity and obesity-related diseases

S Coppola, C Avagliano, A Calignano, R Berni Canani - Molecules, 2021 - mdpi.com
Worldwide obesity is a public health concern that has reached pandemic levels. Obesity is
the major predisposing factor to comorbidities, including type 2 diabetes, cardiovascular …

The role of gut microbiota on cholesterol metabolism in atherosclerosis

M Vourakis, G Mayer, G Rousseau - International Journal of Molecular …, 2021 - mdpi.com
Hypercholesterolemia plays a causal role in the development of atherosclerosis and is one
of the main risk factors for cardiovascular disease (CVD), the leading cause of death …

[HTML][HTML] Role of butyrate, a gut microbiota derived metabolite, in cardiovascular diseases: A comprehensive narrative review

P Amiri, SA Hosseini, S Ghaffari, H Tutunchi… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases (CVD) are major causes of death worldwide. Recently, new roles
for intestinal microbiota in pathology and treatment of CVD have been proposed. Butyrate, a …

Implication of gut microbiota in cardiovascular diseases

W Zhou, Y Cheng, P Zhu, MI Nasser… - Oxidative medicine …, 2020 - Wiley Online Library
Emerging evidence has identified the association between gut microbiota and various
diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has …

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

X Li, C Su, Z Jiang, Y Yang, Y Zhang, M Yang… - npj Biofilms and …, 2021 - nature.com
Abstract Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite
trimethylamine (TMA), has been identified to be an independent risk factor for promoting …

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial …

XC Lv, Q Wu, YJ Cao, YC Lin, WL Guo, PF Rao… - Food & Function, 2022 - pubs.rsc.org
Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has
become a global public threat to human health. It is well known that Ganoderma lucidum has …

Molecular mechanisms of obesity-linked cardiac dysfunction: an up-date on current knowledge

J Gutiérrez-Cuevas, A Sandoval-Rodriguez… - Cells, 2021 - mdpi.com
Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …