The immune-cell origin of hematologic malignancies provides a unique avenue for the
understanding of both the mechanisms of immune responsiveness and immune escape …

In cancer treatment, the first-generation, cytotoxic drugs, though effective against cancer
cells, also harmed healthy ones. The second-generation targeted cancer cells precisely to …

Simple Summary Several factors, both patient-and disease-related, are essential to
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …

Abstract Background t (8; 21)(q22; q22) is one of the most frequent chromosomal
abnormalities in acute myeloid leukemia (AML), leading to the generation of the fusion …

Simple Summary Myelodysplastic neoplasms and acute myeloid leukemias are often
caused by gene mutations. Next generation sequencing (NGS) has become indispensable …

PI3Kδ is an essential target correlated to the occurrence and development of acute myeloid
leukemia (AML). Herein, we investigated the pyrazolo [3, 4-d] pyrimidine derivatives as …

Simultaneous inhibition of PI3K and HDAC has shown promise for treating various cancers,
leading to discovery and development of their dual inhibitors as novel anticancer agents …

Background Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor
outcomes, especially in older AML patients. Tumor necrosis factor-related apoptosis …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and its
incidence increases with higher age. Currently, the median age at diagnosis in western …

Unlike genomic alterations, gene expression profiles have not been widely used to refine
cancer therapies. We analyzed transcriptional changes in acute myeloid leukemia (AML) …