Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and
represents a potential target for therapy. The majority (> 80%) of high grade serous, low …

Cancer is a major public health issue and represents the second leading cause of death in
women worldwide, as female reproductive-related neoplasms are the main cause of …

Ovarian cancer (OC) remains the leading cause of mortality due to gynecological
malignancies. Epidemiological studies have demonstrated that steroid hormones released …

It is known that estrogen stimulates growth and inhibits apoptosis through estrogen receptor
(ER)-mediated mechanisms in many cancer cell types. Interestingly, there is strong evidence …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

The role of 17β-estradiol (E2) in breast cancer development and tumor growth has
traditionally been attributed exclusively to the activation of estrogen receptor-α (ERα) …

Epithelial–mesenchymal transition (EMT) is an important process appearing in embryo
development and tumor migration or progression, which is influenced by 17β-estradiol (E2) …

Estrogens play a crucial role in the regulation of physiological and pathophysiological
processes. These hormones act through specific receptors, most notably the canonical …

Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but
rather by acting via G protein‐coupled estrogen receptors (GPER). To determine if …