Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

Studies that concern the mechanism of DNA replication have provided a major framework
for understanding genetic transmission through multiple cell cycles. Recent work has begun …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

The centromere is responsible for accurate chromosome segregation. Mammalian
centromeres are specified epigenetically, with all active centromeres containing centromere …

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated
by kinetochores, which are unique chromosomal sites for microtubule attachment …

The assembly of just a single kinetochore at the centromere of each sister chromatid is
essential for accurate chromosome segregation during cell division. Surprisingly, despite …