Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Importance Insomnia disorder is prevalent and associated with health risks in older adults;
however, efficacy and safety issues with existing treatments create significant unmet needs …

Abstract Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only
metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also …

The last four decades, we assist to an increasing scientific interest on melatonin, a circadian
hormone, a metabolic regulator which influences not only plants' metabolism and their …

Tricyclic antidepressants (TCAs) were originally designed and marketed for treating
depression, but over time they have been applied to a variety of conditions, mostly offlabel …

Sleep disturbance can negatively affect physical and psychological health. Hypnotherapy
may be effective for improving sleep with fewer side effects than other treatments. The …

Melatonin is the main hormone involved in the control of the sleep-wake cycle. It is easily
synthesisable and can be administered orally, which has led to interest in its use as a …

Background This study focuses on seven commonly used hypnotics to comprehensively
analyze the effects of long-and short-term use on sleep outcomes among adults and older …

(1) Background: To know the medical documentation related to exogenous melatonin in
sleep disorders caused by shift work in health personnel;(2) Methods: Systematic and critical …