The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Ubiquitylation is a critical post-translational modification that controls a wide variety of
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …