The role of reactive oxygen species and its effects on aging has received considerable
attention in the past 47 years since Dr. Denham Harman first proposed the “free radical …

The mitochondrial permeability transition pore (PTP) and associated release of cytochrome
c are thought to be important in the apoptotic process. Nitric oxide (NO⋅) has been reported …

Mitochondrial nitric oxide synthase (mtNOS), its cellular NOS isoform, and the effects of
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …

Increasing evidence suggests an important role of mitochondrial dysfunction in the
pathogenesis of Alzheimer's disease. Thus, we investigated the effects of acute and chronic …

Since its initial discovery as an endogenously produced bioactive mediator, nitric oxide (•
NO) has been found to play a critical role in the cellular function of nearly all organ systems …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

There has been increasing interest, in recent years, in the possibility that reactive
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …

Activation of murine microglial and macrophage cell lines with lipopolysaccharide (LPS) and
interferon‐γ (IFN‐γ) resulted in the induction of the inducible form of nitric oxide synthase …

The experimental evidence for an age-dependent increased generation of reactive oxygen
species and a progressive accumulation of oxidized biomolecules is growing. However …

Mitochondrial nitric oxide synthase (mtNOS) is expressed constitutively, although it might be
induced. Nitric oxide (NO) is a physiological regulator of mitochondrial respiration. Melatonin …